Association of Rantes Gene -403 G/A Polymorphism with Allergic Rhinitis Patients

Currently allergic rhinitis is accepted to be multi factorial disease. Inherited susceptibility plays a major role along with the other environmental factors in the development of this disease. Therefore, it is important to search for genetic markers, associated with the development of allergic rhinitis that enables us to understand the pathogenesis, treatment and prevention of the disease. This work pursues molecular analysis of polymorphous variants of RANTES -403 G/A gene and evaluates its genetic marker in the development of allergic rhinitis. This was done by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results revealed increases the frequency of A-403 allele among allergic rhinitis patients with significantly difference as compared to the control subjects (P < 0.001). The frequency of homozygotes (A/A) allele was significantly higher among allergic rhinitis patients with nasal polyps and asthma than other comorbid disorders (P < 0.001). This suggests the association between the gene under study and the development of allergic rhinitis. RANTES A-403 may increase genetic susceptibility to allergic rhinitis and may be used as predictor gene set for allergic rhinitis and in genomic analysis. However, further population and functional studies are necessary to clarify the roles of the polymorphisms in allergic rhinitis.